Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9191939 | Experimental Neurology | 2005 | 7 Pages |
Abstract
Brain injury secondary to hypoxic-ischemic disease is the predominant form of damage encountered in the perinatal period. The impact of neonatal hypoxia-ischemia (HI) in 7-day-old pups on the high-affinity [3H] glutamate uptake into hippocampal slices at different times after insult was examined. Immediately following, and 1 day after the insult there was no effect. But at 3 to 5 days after the HI insult, glutamate uptake into the hippocampus was markedly reduced; however, after 30 or 60 days the glutamate uptake into hippocampal slices returned to control levels. Also, this study demonstrated the effect of the nucleoside guanosine (Guo) on the [3H] glutamate uptake in neonatal HI injury, maintaining the [3H] glutamate uptake at control levels when injected before and after insult HI. We conclude that neonatal HI influences glutamate uptake a few days following insult, and that guanosine prevents this action.
Related Topics
Life Sciences
Neuroscience
Neurology
Authors
M.B. Moretto, N.S. Arteni, D. Lavinsky, C.A. Netto, J.B.T. Rocha, D.O. Souza, S. Wofchuk,