Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9192005 | Experimental Neurology | 2005 | 5 Pages |
Abstract
Stroke induced by 2 h middle cerebral artery occlusion triggers increased striatal and hippocampal neurogenesis in adult rats. We investigated the effect of tumor necrosis factor-α (TNF-α) inhibition on the survival of the new neurons. The mitotic marker BrdU was given on days 5 to 7, and TNF-α antibody or control protein was infused into the lateral ventricle of the ischemic hemisphere from day 8 to 14 after stroke. At the end of infusions, the TNF-α antibody-treated rats showed markedly fewer new striatal and hippocampal neurons, as compared to animals given control protein. The present findings suggest that TNF-α, probably acting via its receptor TNFR2, can promote the survival of stroke-generated hippocampal and striatal neurons.
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Authors
Ursula Heldmann, Pär Thored, Jan-Hendrik Claasen, Andreas Arvidsson, Zaal Kokaia, Olle Lindvall,