Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9192037 | Experimental Neurology | 2005 | 9 Pages |
Abstract
The presence of α6 subunit containing nicotinic acetylcholine receptors on nigrostriatal dopaminergic neurons has been demonstrated in rodents and monkeys. [125I]α-conotoxinMII is a radioligand that binds to α6, and also α3 subunits of nicotinic acetylcholine receptors (nAChRs). In the present study, we have compared the distribution of [125I]α-conotoxinMII binding in post mortem human tissue from four groups of patients: individuals with dementia with Lewy bodies displaying extra-pyramidal features (DLB + EPF), DLB without extra-pyramidal features (DLB â EPF) Parkinson's disease without dementia (PD) and age-matched controls. Reduced binding was observed in the putamen and caudate in PD and both DLB groups. In DLB patients, the decline was greater in DLB + EPF compared to DLB â EPF group. The declines in nicotinic receptor binding in the striatum were in part paralleled by reductions in the striatal dopamine transporter. In the thalamus, [125I]α-conotoxinMII binding was significantly reduced in the centromedian nucleus in both DLB groups, and also in the parafascicular nucleus in the DLB â EPF group. In DLB + EPF and PD patients, there was decreased binding in the ventral lateral nucleus. This study demonstrates alterations of α6 and/or α3 nAChRs binding in DLB and PD, which are likely to relate to extra-pyramidal symptoms.
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Authors
I.J. Bohr, M.A. Ray, J.M. McIntosh, S. Chalon, D. Guilloteau, I.G. McKeith, R.H. Perry, F. Clementi, E.K. Perry, J.A. Court, M.A. Piggott,