Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9192142 | Experimental Neurology | 2005 | 9 Pages |
Abstract
Ischaemic, excitotoxic and traumatic brain injuries have been associated with the occurrence of epileptic seizures. Microglia, the principal immune cells in the brain, produce a variety of proinflammatory and cytotoxic factors especially interleukin-1 (IL-1) early after an acute insult. We studied the effect of intracerebroventricularly administered IL-1β on seizure acquisition and on fully kindled seizures in amygdala kindling model of epilepsy. IL-1β (0.01 ng/rat) retarded acquisition of kindled behavioral seizures and growth of afterdischarges (AD). IL-1β (0.01-10 ng/rat) also exhibited significant anticonvulsant effect on established kindled seizures and AD duration. This effect began 0.5 h after administration and was continued up to 72 h. Pretreatment of the kindled animals with nitric oxide synthase inhibitor, NG-nitro-l-arginine methyl ester, or cyclooxygenase inhibitor, piroxicam, reversed the anticonvulsant effect of IL-1β at early time points. Although most of the previous studies indicate a proconvulsant or convulsant property of IL-1, our results support a protective and antiepileptogenic role of IL-1β.
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Authors
M. Sayyah, S. Beheshti, M.A. Shokrgozar, A. Eslami-far, Z. Deljoo, A.R. Khabiri, A. Haeri Rohani,