Rhythmic brain activity at rest from rolandic areas in acute mono-hemispheric stroke: A magnetoencephalographic study

A lesion affecting the MCA territory of one hemisphere induces a perilesional increase of the low-frequency rhythms' spectral power within the AH rolandic areas; the same effect was present also in the UH, indicating interhemispheric diaschisis. In the AH, results showed an increase of the total power and a reduction of the spectral entropy, suggesting a higher synchrony of local neuronal activity, a reduction of the intra-cortical inhibitory networks efficiency and an increase of neuronal excitability. Direct correlation linked gamma band activity preservation and less severe clinical status. Dependence of the clinical picture, and associated spectral alterations, on the lesion volume and not on the lesion level, suggests a diffuse neuronal impairment, rather than a selective structures damage, contributing to neurological status in the acute phase of stroke.