Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9198184 | NeuroImage | 2005 | 9 Pages |
Abstract
Meta-analysis: We pooled 472 relatives and 513 controls. The P300 amplitude was significantly reduced in relatives (PSESÂ =Â 0.61; 95% CI: 0.30 to 0.91; PÂ <Â 0.001). The P300 latency was significantly delayed in relatives (PSES of â0.50; 95% CI: â0.88 to â0.13; PÂ =Â 0.009]. Local study: The patients showed a trend for amplitude reductions (PÂ =Â 0.06) and significant latency delays (PÂ <Â 0.01). The relatives displayed normal amplitude but had significant latency delays (PÂ =Â 0.01). The P300 amplitude and especially the P300 latency are promising alternative phenotypes for genetic research into schizophrenia.
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Authors
Elvira Bramon, Colm McDonald, Rodney J. Croft, Sabine Landau, Francesca Filbey, John H. Gruzelier, Pak C. Sham, Sophia Frangou, Robin M. Murray,