Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9198187 | NeuroImage | 2005 | 11 Pages |
Abstract
Despite no significant differences being found in the subjective ratings of affective pictures across three sessions, compared to placebo, acute treatments of DA D2 receptor antagonists and SSRIs commonly attenuated the amygdala activity, although both treatments had slightly different modulatory effects on other components of the neural circuit of emotional processing. This study has shown that even acute treatment of drugs that manipulate neurotransmitter systems could affect brain activation associated with emotional processing in human brain. At the same time, our findings suggest that pharmacological fMRI could be a powerful tool for investigating the neurophysiological properties of drugs targeting neuropsychiatric disorders.
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Cognitive Neuroscience
Authors
Hidehiko Takahashi, Noriaki Yahata, Michihiko Koeda, Akihiro Takano, Kunihiko Asai, Tetsuya Suhara, Yoshiro Okubo,