Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9207912 | Burns | 2005 | 7 Pages |
Abstract
Thirty Wistar rats were randomly divided into five groups. Sham group (n = 6) was exposed to 21 °C water while burn-3 h group (n = 6) and burn + trap-3 h group (n = 6), burn-24 h (n = 6) and burn + trap-24 h groups were exposed to boiling water for 12 s to produce a full thickness burn in 35-40% of total body surface area. In both burn + trap-3 h and burn-trap-24 h group, 8 mg/kg trapidil was given intravenously immediately after thermal injury. Three and 24 h later, tissue samples were taken for biochemical analysis from lung, intestine and kidney and blood samples were obtained to determinate serum TNF-α levels. Cutaneous thermal injury caused a significant increase in myeloperoxidase (MPO) activity and malondialdehyde (MDA) and 3-nitrotyrozine (3-NT) levels in all tissues and elevated serum TNF-α levels at post-burn 3 and 24 h. Trapidil treatment significantly reduced in biochemical parameters, as well as serum TNF-α levels. These data suggest that trapidil has a protective effect against oxidative organ damage in burn injury.
Related Topics
Health Sciences
Medicine and Dentistry
Critical Care and Intensive Care Medicine
Authors
Dinçer Avlan, Hakan TaÅkinlar, Lilüfer Tamer, Handan Ãamdeviren, Hakan Ãzturhan, Candan Ãztürk, Selim Aksöyek,