De l'usage des concentrés plaquettaires autologues en application topique

Research for protocols supporting haemostasis and cicatrisation is a recurrent problem in all types of surgery. Platelet concentrates, as cytokines-enriched biological adhesives constitute some novel research fields. The first generation of these surgical additives, generally named cPRP (concentrated platelet-rich plasma), come from the autologous fibrin adhesives technologies. The different kinds of cPRP were tested in many clinical situations, particularly in oral and maxillofacial surgery. Moreover, the second platelet concentrate generation, the PRF (platelet-rich fibrin), offers the more efficient clinical applications. Indeed, PRF induces accelerated tissue healing owing to the development of effective neovascularization, accelerated wound closing with fast cicatricial tissue remodelling and almost total absence of infectious events. Platelet concentrates for topical use, particularly the PRF, thus represent some new complementary therapeutic additives, provided its real effects are impartially and strictly evaluated.