Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9211652 | Journal of Endodontics | 2005 | 5 Pages |
Abstract
The influence of NK1 receptor antagonists applied iontophoretically on pulpal blood flow (PBF) was investigated. Along with substance P (SP, 0.8â¼20.0 ng/kg) administration to the canine pulp through the catheterized lingual artery, two NK1 receptor antagonists, [D-Pro2,D-Trp7,9]-SP and [D-Pro2,D-Phe7,D-Trp9]-SP (0.2â¼3.4 mM) were applied iontophoretically (cathodal current, 0.02â¼0.1 mA, 1 min) to the prepared class V dentinal cavity of ipsilateral teeth in 11 generally anesthetized cats. A paired t-test showed that SP administration caused significant increases of PBF (p < 0.05) without changing systemic blood pressure, and that SP and SP antagonist administration caused significantly less increase of PBF than in control of SP and 0.9% saline administration (p < 0.05). These data provide evidence that the iontophoretic application of NK1 receptor antagonists effectively attenuates SP-induced vasodilatation and show the possibility of their use in the control of neurogenic inflammation in the dental pulp.
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Authors
Young-Kyung DDS, PhD, Wan-sik DDS, MsD, Ho-Jeong BSc, Dong-Kuk DDS, PhD, Sung Kyo DDS, PhD,