| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9212062 | Journal of Endodontics | 2005 | 4 Pages |
Abstract
Hyaluronan (HA), is a high molecular mass extracellular matrix constituting connective tissue and plays a critical role in not only homeostasis but also inflammatory and wound-healing responses. In this study, we investigated the effect of fibroblast growth factor (FGF)-2 on the production of HA by human dental pulp cells (HDPC). An inhibition binding-protein assay showed that FGF-2 increased HA production by HDPC. In addition, expression of mRNA of hyaluronan synthase (HAS) 1 and HAS 2, both of which are related to the production of high molecular mass of HA, but not HAS 3, was enhanced in FGF-2-stimulated HDPC. These results provide new evidence for the involvement of FGF-2 in the regulation of HA production by HDPC possibly through HAS 1 and HAS 2.
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Authors
Yoshio Shimabukuro, Maki Ueda, Tomoo Ichikawa, Yoshimitsu ma, Satoru Yamada, Yutaka Kusumoto, Masahide Takedachi, Mami Terakura, Akira ma, Tomoko Hashikawa, Shinya Murakami,