Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9216588 | Oral Oncology | 2005 | 5 Pages |
Abstract
To define the role of surgical management of lung metastases in ACC. Twenty ACC patients referred to lung metastasectomy were retrospectively reviewed. Twenty-six operations were performed; at the first metastasectomy, a resection with clear margins (R0) was achieved in 11 patients (55%), 3 are alive and well. Four out of 9 patients with residual disease (R2) are still alive. Median survival after metastasectomy was 78 and 52 months for R0 and R2 (p = 0.4); median freedom from progression (FFP) in R0 and R2 groups was 30 and 15 months (p = 0.2), respectively. A better outcome was obtained for patients with a disease-free interval ⩾36 months and ⩾6 metastases and bilateral involvement were critical in achieving a R0 intervention. Lung metastasectomy provided a prolonged FFP in a high selected subset of patients with ACC. However, if this could be translated into a survival benefit, it is still to be demonstrated.
Keywords
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Dentistry, Oral Surgery and Medicine
Authors
Laura D. Locati, Marco Guzzo, Paolo Bossi, Paolo P. Brega Massone, Barbara Conti, Elena Fumagalli, Claudia Bareggi, Giulio Cantù, Lisa Licitra,