Performance and safety of skin allografts

Skin preservation for transplantation began almost 200 years ago with the pioneering work of Baronio (cited by in Ref. 2). Since that time, hundreds of papers have been published on the preservation of skin for later application in wound treatment. This interest stems from the excellent clinical results obtained with skin as a permanent autograft or temporary allograft for wound cover, coupled with the relative ease of preservation and storage methods. The general recognition of the need for human skin allografts has stimulated the establishment of banking facilities and research to improve the methods for harvesting, processing, storage, and subsequent evaluation of transplantation performance.