Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9225563 | Journal of Allergy and Clinical Immunology | 2005 | 7 Pages |
Abstract
Our results demonstrate the dual nature of corticosteroids. Although corticosteroids can downregulate the expression of some asthma-associated chemokines, such as eotaxin, MCP-3, and MCP-4, they can also upregulate the expression of other chemokines, including IL-8, IP-10, and MCP-2. The failure of oral corticosteroids to inhibit IL-8 mRNA expression might contribute to persistent airway neutrophilia observed in patients with moderate-to-severe asthma, despite treatment with corticosteroids.
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Authors
Motonori MD, PhD, Celine MD, MSc, Meri K. PhD, Pierre-Olivier BSc, Oday MSc, Michel MD, Qutayba MD, PhD, Jamila PhD,