Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9226769 | Journal of Allergy and Clinical Immunology | 2005 | 8 Pages |
Abstract
Asthma is a disease characterized, in part, by airway hyperresponsiveness and inflammation. Although asthma typically induces reversible airway obstruction, in some patients with asthma, airflow obstruction can become irreversible. Such obstruction might be a consequence of persistent structural changes in the airway wall caused by the frequent stimulation of airway smooth muscle (ASM) by contractile agonists, inflammatory mediators, and growth factors. Traditional concepts concerning airway inflammation have focused on trafficking leukocytes and on the effects of inflammatory mediators, cytokines, and chemokines secreted by these cells. Recent studies suggest that ASM cells might modulate airway remodeling by secreting cytokines, growth factors, or matrix proteins and by expressing cell adhesion molecules and other potential costimulatory molecules. These ASM cell functions might directly or indirectly modulate submucosal airway inflammation and promote airway remodeling.
Keywords
ASMRTKPDGFLTD4GPCRERKMCPMMPECMPI3KSynthetic functionG protein–coupled receptorADAMAsthmaSTATProliferationsmooth muscle Airway smooth muscleVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)platelet-derived growth factorPhosphatidylinositol 3-kinaseLeukotriene D4Extracellular matrixmatrix metalloproteinaseSignal transducer and activator of transcriptionSignal transductionmonocyte chemotactic proteinextracellular signal-regulated kinaseReceptor Tyrosine Kinase
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Authors
Aili L. MD, Reynold A. MD,