| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9226777 | Journal of Allergy and Clinical Immunology | 2005 | 6 Pages |
Abstract
Fluticasone plasma concentrations are significantly greater after MDI compared with DPI, and cortisol suppression is associated with fluticasone plasma concentrations. Accumulation of fluticasone concentrations suggests that time to steady state exceeds 1 week of treatment with MDI.
Keywords
Cortisol suppressionMDIICSFPDDPICFCMMADFPFAUCDiCEDrug accumulationSteady stateMetered Dose InhalerMetered-dose inhalerfine particle doseemitted dosePharmacokineticsFluticasone propionateMass median aerodynamic diameterarea under the curveMiceDry powder inhalerFine particle fractionchlorofluorocarbonInhaled corticosteroid
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Authors
Glenn J. PharmD, Jeffrey L. MD, PhD, Richard J. MD, Stanley J. MD,