Article ID Journal Published Year Pages File Type
9227081 Journal of Allergy and Clinical Immunology 2005 7 Pages PDF
Abstract
T regulatory (Treg) cells play a key role in the modulation of allergic and autoimmune responses. This review will discuss the factors that regulate naturally occurring Treg (nTreg) cell-mediated suppression. The involvement of cytokines, costimulatory molecules, and ligands on antigen-presenting cells in the inhibition of nTreg cell-mediated suppression in vitro is summarized. Understanding the events that control suppressive function of nTreg cells will allow manipulation of these cells to inhibit or enhance their functions in the development of novel therapies for autoimmune and allergic diseases.
Related Topics
Life Sciences Immunology and Microbiology Immunology
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