Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9227081 | Journal of Allergy and Clinical Immunology | 2005 | 7 Pages |
Abstract
T regulatory (Treg) cells play a key role in the modulation of allergic and autoimmune responses. This review will discuss the factors that regulate naturally occurring Treg (nTreg) cell-mediated suppression. The involvement of cytokines, costimulatory molecules, and ligands on antigen-presenting cells in the inhibition of nTreg cell-mediated suppression in vitro is summarized. Understanding the events that control suppressive function of nTreg cells will allow manipulation of these cells to inhibit or enhance their functions in the development of novel therapies for autoimmune and allergic diseases.
Keywords
NFATCTLA-4IPEXGITRhuman T-cell lymphotropic virus type 1HTLV-1TLRAPCNF-κBcytotoxic T lymphocyte–associated antigen 4antigen-presenting cellToll-like receptorAtopic dermatitisImmune suppressionRegulatory T cellTreg cellT regulatory cellssuperantigensNuclear Factor of Activated T Cellsnuclear factor κB
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Authors
Elena PhD, Ivan D. MD, Liang-Shiou MD, Donald Y.M. MD, PhD,