Predictors of immunologic long-term nonprogression in HIV-infected children: Implications for initiating therapy

Article ID	Journal	Published Year	Pages	File Type
9227700	Journal of Allergy and Clinical Immunology	2005	8 Pages	PDF

Abstract

CD8+ HLA-DR+ T-lymphocyte percentage of less than 5% at 1 to 2 months of age might be predictive for ILTNP status but should not be used at this time to make treatment-deferral decisions. Immune activation in HIV-infected infants might herald more disease progression. Further study of the use of this subpopulation in early infancy to predict ILTNP status is warranted.

Keywords

ROC PCP HAART Long-term nonprogressor WITS Women and Infants Transmission Study LTNP Quality assurance highly active antiretroviral therapy CD8+ T lymphocyte odds ratio human immunodeficiency virus Perinatal receiver operating characteristic

Related Topics

Life Sciences Immunology and Microbiology Immunology

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Predictors of immunologic long-term nonprogression in HIV-infected children: Implications for initiating therapy

Authors

Mary E. MD, Charlotte MD, Manhattan PhD, Leslie MD, Marc MD, Karen MD, Edward L. MD, Clemente MD, Kenneth MD, William T. MD, PhD, for the Women and Infants Transmission Study for the Women and Infants Transmission Study,