Jun N-terminal kinase is essential for CD40-mediated IgE class switching in B cells

Article ID	Journal	Published Year	Pages	File Type
9227701	Journal of Allergy and Clinical Immunology	2005	8 Pages	PDF

Abstract

These results demonstrate that JNK activation is essential for CD40-mediated CSR to IgE and suggest that JNK is important for AID activity in B cells.

Keywords

Jnk TNF receptor–associated factor Ung Uracil-N-glycosylase TRAF CD40L Activation-induced cytidine deaminase CD40 NF-κB ERK AP-1 CSR c-Jun N-terminal kinase GLT MAPK class switch recombination Isotype switching Germline transcript B cells nuclear factor κB CD40 ligand activation protein 1 mitogen-activated protein kinase AID Extracellular signal–regulated kinase