Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9230067 | Journal of Dermatological Science Supplement | 2005 | 7 Pages |
Abstract
UVA, TNF-α and IL-1β inhibit COL7A1 expression at the transcriptional level by acting on nucleotides â524 to â22 of the promoter region. These results suggest that UVA-induced downregulation of COL7A1 transcription in epidermal keratinocytes diminishes anchoring fibrils formation, resulting in skin fragility. Additional external factors including physical forces and UVB radiation in the sun-exposed areas may further promote deep wrinkle formation.
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Authors
Atsushi Kon, Hitoshi Takeda, Noriko Ito, Katsumi Hanada, Keiichi Takagaki,