Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9230302 | Journal of Investigative Dermatology | 2005 | 12 Pages |
Abstract
Surface epithelial cells, such as the epidermal keratinocyte, undergo a process of terminal cell differentiation that results in the construction of a multilayered epithelium. This epithelium functions to protect the organism from the environment. Transglutaminases, enzymes that catalyze the formation of isopeptide protein-protein cross-links, are key enzymes involved in the construction of this structure. This brief review will focus on the role of these enzymes in constructing the epidermal surface.
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Authors
Richard L. Eckert, Michael T. Sturniolo, Ann-Marie Broome, Monica Ruse, Ellen A. Rorke,