Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9230335 | Journal of Investigative Dermatology | 2005 | 11 Pages |
Abstract
Neurotrophins are important modulators of epithelial-mesenchymal interactions. Previously, we had shown that brain-derived neurotrophic factor (BDNF) and its high-affinity receptor tyrosine kinase B (TrkB) are prominently involved in the control of murine hair follicle cycling. We now show that BDNF and TrkB are also expressed in the human hair follicle in a manner that is both hair cycle dependent and suggestive of epithelial-mesenchymal cross-talk between BDNF-secreting dermal papilla fibroblasts of anagen hair follicles and subpopulations of TrkB+ hair follicle keratinocytes. As functional evidence for an involvement of BDNF/TrkB in human hair growth control, we show in organ-cultured human anagen hair follicles that 50 ng per mL BDNF significantly inhibit hair shaft elongation, induce premature catagen development, and inhibit keratinocyte proliferation. Quantitative real-time rtPCR analysis demonstrates upregulation of the potent catagen inducer, transforming growth factor β2 (TGFβ2) by BDNF, whereas catagen induction by BDNF was partially reversible through co-administration of TGFβ-neutralizing antibody. This suggests that TrkB-mediated signaling promotes the switch between anagen and catagen at least in part via upregulation of TGFβ2. Thus, human scalp hair follicles are both a source and target of bioregulation by BDNF, which invites to target TrkB-mediated signaling for therapeutic hair growth modulation.
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Authors
Eva M.J. Peters, Marit G. Hansen, Rupert W. Overall, Motonobu Nakamura, Paolo Pertile, Burghard F. Klapp, Petra C. Arck, Ralf Paus,