Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9236341 | Best Practice & Research Clinical Gastroenterology | 2005 | 10 Pages |
Abstract
Neuroendocrine tumours (NETs) of the appendix (formerly 'carcinoids') are rare and are usually detected incidentally after appendectomy. Histopathologically they derive from a subepithelial cell population, which is different from NETs in other sites. They are preferentially located at the tip of the appendix. Tumours <1Â cm hardly ever metastasize and are treated by appendectomy. Tumours >2Â cm require right hemicolectomy because of a significant risk of metastatic spread. Treatment for lesions 1-2Â cm is controversial and needs further characterization of the tumour (i.e. mesoappendiceal invasion, vascular invasion, mitotic activity, proliferation markers) and careful patient risk evaluation. Goblet-cell carcinoids have features resembling both carcinoid and adenocarcinoma and should be treated by hemicolectomy. Overall prognosis of small appendiceal NET is excellent in all ages.
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Authors
B. (Professor), M. (Professor),