La terapia hormonal sustitutiva: mandan las evidencias

Hormone replacement therapy has been successfully used for decades not only to control menopausal symptoms, for which is has been proven effective, but also, based on several observational studies, as a primary intervention for cardiovascular diseases, osteoporosis, cognitive impairment and dementias. As a result, it has become one of the most frequently used preventive measures. Recent randomized and controlled studies, the WHI in particular, have shown, however, that while hormone replacement therapy does offer protection against osteoporotic bone fractures and, to a lesser extent, colon carcinoma, it does not offer cardiovascular protection, supposedly the most beneficial aspect of treatment, observing actually a slight increment of the risk of coronary heart disease, stroke, invasive breast cancer, thromboembolic disease and dementia. In this review the current evidences about risk and benefits of hormone replacement therapy are analysed.