Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9244303 | Gastroenterology | 2005 | 14 Pages |
Abstract
Conclusions: GH resistance in experimental colitis is caused by down-regulation of GHR expression, thereby reducing GH-dependent STAT5 activation. TNFα blockade restores liver GH signaling and improves anabolic metabolism in this setting.
Keywords
GHREMSATNFIGFBP-3IGF-1BMDFFMGAPDHElectrophoretic mobility shift assaySTATAcid labile subunitinterleukinALSBone mineral densityFat Free Massinsulin-like growth factor 1tumor necrosis factorSignal transducer and activator of transcriptionwild typeGrowth hormonepolymerase chain reactionPCRInsulin-like growth factor binding protein 3glyceraldehyde-3-phosphate dehydrogenasegrowth hormone receptor
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Authors
Lisa M. Difedele, Jiman He, Erin L. Bonkowski, Xiaonan Han, Matthew A. Held, Alan Bohan, Ram K. Menon, Lee A. Denson,