| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9253783 | Journal of Hepatology | 2005 | 10 Pages |
Abstract
Oatp2 and Mrp2 expression is decreased in fatty liver and may impair metabolism and biliary secretion of numerous xenobiotics. Reduction of bile salt secretion and absence of biliary GSH excretion may contribute to impaired bile flow and posthepatic disorders associated with biliary GSH depletion.
Keywords
BSEPS-(2,4-dinitrophenyl)glutathioneγ-GCSOATPPXRNtcpRXRRARNAFLFXRRetinoid X receptorBcrpMRPCDNBMDRGGTGSHPhIPGSTGSSG1-chloro-2,4-dinitrobenzene2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridinefarnesoid X receptorHnfγ-glutamylcysteine synthetaseNon-alcoholic steatohepatitisBile acidsSteatosisorganic anion transportMultidrug resistance transporterhepatocyte nuclear factorCARNash isolated rat liver perfusionbreast cancer resistance proteinsodium taurocholate cotransporting polypeptideOrganic anion transporting polypeptideBile salt export pumpreduced glutathioneNon-alcoholic fatty liverGlutathione conjugatesGlutathioneglutathione S-transferaseglutathione disulfideconstitutive androstane receptorRetinoic acid receptorPregnane X receptor
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Authors
Andreas Geier, Christoph G. Dietrich, Tobias Grote, Ulrich Beuers, Thomas Prüfer, Peter Fraunberger, Siegfried Matern, Carsten Gartung, Alexander L. Gerbes, Manfred Bilzer,