| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9253786 | Journal of Hepatology | 2005 | 10 Pages |
Abstract
Mdr2-/- mice spontaneously progress to severe biliary fibrosis. This is due to a characteristic temporal pattern of upregulated profibrogenic and downregulated fibrolytic genes and activities. These mice are an attractive model to test potential antifibrotics for the treatment of (biliary) liver fibrosis.
Keywords
HYPTGF-βMdr2ProcollagenTIMP-1PDGFR-βα-SMAPAI-1PSCTGFβHSCMMPα-smooth muscle actintransforming growth factor-βTIMPHepatic stellate cellLiver fibrosismatrix metalloproteinaseBile ductAnimal modeltissue inhibitor of matrix metalloproteinasesPlasminogen activator inhibitor-1Knockout miceMyofibroblasthydroxyprolinePrimary sclerosing cholangitisCollagenPDGF receptor
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Authors
Yury Popov, Eleonora Patsenker, Peter Fickert, Michael Trauner, Detlef Schuppan,