| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9253847 | Journal of Hepatology | 2005 | 8 Pages |
Abstract
The data demonstrate that multiple abnormalities in the members of the Wnt pathway lead to nuclear accumulation of β-catenin and suggest that activation of Wnt pathway provides proliferative advantages in c-Myc/E2F1-driven hepatocarcinogenesis.
Keywords
PCNAsFRPE2F1DVLfrizzledAPCGSK-3βMSIc-MycGLTHCCadenomatous polyposis coliProliferating Cell Nuclear Antigenloss of heterozygosityImmunohistochemistryIHCβ-cateninMicrosatellite instabilitydishevelledHepatic tumorsGlutamate transporterLOHTransgenic mouse modelsSecreted frizzled-related proteinFrzHepatocellular carcinomaGlycogen synthase kinase-3β
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Authors
Diego F. Calvisi, Elizabeth A. Conner, Sara Ladu, Eric R. Lemmer, Valentina M. Factor, Snorri S. Thorgeirsson,