| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9253880 | Journal of Hepatology | 2005 | 7 Pages |
Abstract
HCV core protein down-regulates the expression of SOCS-1 gene. This is a mechanism leading to SOCS-1 silencing, an alternative to the hypermethylation of the gene; this effect of the core protein may modulate the intracellular signaling pathway, contributing to the pathogenesis in HCV infection including hepatocarcinogenesis.
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Authors
Hideyuki Miyoshi, Hajime Fujie, Yoshizumi Shintani, Takeya Tsutsumi, Seiko Shinzawa, Masatoshi Makuuchi, Norihiro Kokudo, Yoshiharu Matsuura, Tetsuro Suzuki, Tatsuo Miyamura, Kyoji Moriya, Kazuhiko Koike,