Overexpression of thioredoxin prevents thioacetamide-induced hepatic fibrosis in mice

Article ID	Journal	Published Year	Pages	File Type
9254855	Journal of Hepatology	2005	7 Pages	PDF

Abstract

Thioredoxin has a potential to attenuate hepatic fibrosis via suppressing oxidative stress and inhibiting proliferation of stellate cells.

Keywords

PDTC ALT PAGE ERK GAPDH NAC MTS AP-1 CHX PDGF Trx FBS Ref-1 SDS Redox factor-1 MDA DMEM TAA LPS TNF PBS adult T cell leukemia-derived factor HSC NF-κB ADF Dulbecco's modified Eagle Medium N-acetylcysteine ROS Hydrogen peroxide AST Aspartate aminotransferase Alanine aminotransferase polyacrylamide gel electrophoresis Epstein–Barr interleukin Transgenic thioredoxin Human thioredoxin Thioacetamide SMA pyrrolidine dithiocarbamate sodium dodecylsulfate fetal bovine serum Stellate cell Hepatic stellate cell cycloheximide Smooth muscle α-actin platelet-derived growth factor tumor necrosis factor nuclear factor-κB Hepatic fibrosis lipopolysaccharide malondialdehyde Phosphate-buffered saline wild type H2O2 human immunodeficiency virus HIV activator protein-1 extracellular signal-regulated kinase glyceraldehyde-3-phosphate dehydrogenase Reactive oxygen species

Related Topics

Health Sciences Medicine and Dentistry Gastroenterology

Overexpression of thioredoxin prevents thioacetamide-induced hepatic fibrosis in mice

Authors

Hiroaki Okuyama, Hajime Nakamura, Yasuyuki Shimahara, Naoki Uyama, Yong-Won Kwon, Norifumi Kawada, Yoshio Yamaoka, Junji Yodoi,