| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9257342 | NPG Neurologie - Psychiatrie - Gériatrie | 2005 | 5 Pages |
Abstract
In addition, in brain samples from aged patients with Alzheimer's disease, significant negative correlations are found between the low concentration of some neurosteroids and the elevated levels of beta-amyloid and hyperphosphorylated tau proteins. Thus, neurosteroids appear as good candidates for the prevention and/or the treatment of Alzheimer's disease. If the supplementation with neurosteroids, particularly in well-defined galenic forms, can be considered, the stimulation of their endogenous production by modulating specific pathways of neurosteroidogenesis represents a novel and promising strategy for neuroprotection and restoration of memory deficits.
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Authors
Y. Akwa,