| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9257636 | Critical Reviews in Oncology/Hematology | 2005 | 35 Pages |
Abstract
Hepatocyte growth factor plays multiple roles in cancer, by acting as a motility and invasion stimulating factor, promoting metastasis and tumour growth. Furthermore, it acts as a powerful angiogenic factor. The pivotal role of this factor in cancer has indicated HGF as being a potential target in cancer therapies. The past few years have seen rapid progress in developing tools in targeting HGF, in the context of cancer therapies, including development of antagonists, small compounds, antibodies and genetic approaches. The current article discusses the potential value of HGF and its receptor as targets in cancer therapies, the current development in anti-HGF research, and the clinical value of HGF in prognosis and treatment.
Keywords
ECMCREBEGFREPAPI3KCDKMMPGDICOX-2FAKARPFGFCTGFWASPRASSRCHUVECGABPPARGLAHspABLERMPLCRyRFADDTGFBcl2PAKCMTHIFWntVHLMAP kinase kinaseOPNSREARFICAMHAIRCCHGFuPAcMETRAF-1CrkCrkLwingless-type MMTV integration site familyNK4GRBEDGFLKLIMKHGFATSP1SHC1Ras homolog gene familyTCF-1MIMPBH3 Interacting Domain Death AgonistB-cell CLL/lymphoma 2HCCiGFRMAPKSTATAngiogenesisvon Hippel–Lindau proteinOsteopontinEicosapentaenoic acidHyaluronic acidGamma linolenic acidTemtransforming growth factorchemically modified tetracyclineTrkthrombospondin 1ParEMTCancer therapiesRetinoic acidretinoblastoma 1RhoTIMPHuman umbilical vein endothelial cellsHeparan sulphateCyclooxygenase-2Hepatocyte growth factorScatter factorSerum response elementHypoxia-inducible factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Connective tissue growth factorfibroblast growth factorPhosphatidylinositol 3-kinasephospholipase Curokinase plasminogen activatorHepatocyte growth factor activatorExtracellular matrixSignal transducer and activator of transcriptionCancer metastasisMetalloproteinaseMEKguanine nucleotide dissociation inhibitorTissue inhibitor of metalloproteinaseWaveintercellular adhesion moleculeSignal transductionprotease activated receptorcAMP responsive element binding proteinWiskott–Aldrich syndrome proteinHeat shock proteinActin-related proteinmitogen activated protein kinaseprostaglandinBIDEndothelial differentiation geneRenal cell carcinomaHepatocellular carcinomafocal adhesion kinasecyclin-dependent kinaseEpithelial–mesenchymal transitionglycogen synthase kinase 3 betaAngiotensin II receptorRyanodine receptorEpidermal growth factor receptorInsulin-like growth factor receptorRock
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Authors
Wen G. Jiang, Tracey A. Martin, Christian Parr, Gaynor Davies, Kunio Matsumoto, Toshikazu Nakamura,