Inhibiteurs du fonctionnement plaquettaire

Two broad groups of platelet inhibitors are identified: the activation inhibitors (aspirin, thienopyridines, prostacyclin and its analogues) and the aggregation inhibitors that bind to the glycoproteic complex GPIIb/IIIa. This review includes the basic pharmacology of orally administered platelet inhibitors, together with their conditions of use for the prevention of those thrombotic arterial events that complicate atherosclerosis and in some particular contexts of acquired thrombophilia such as the placental vascular pathology, the myeloproliferative disorders, thrombotic microangiopathy, and the anti-phospholipid syndrome.