| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9261766 | Autoimmunity Reviews | 2005 | 6 Pages |
Abstract
Wegener granulomatosis (WG) belongs to a heterogeneous group of systemic anti-neutrophil cytoplasmatic antibody (ANCA) associated vasculitides (AASV). WG is characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract, glomerulonephritis and vasculitis. As a multifactorial model disease, WG is hallmarked by the presence of specific ANCA-subtypes directed against a defined antigen. WG is more predominant among Caucasians and the genetic predisposition appears quite complex. Here, we provide a brief overview concerning genetic factors in the pathogenesis of WG and discuss intricacies of molecular genetic approaches.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Peter Jagiello, Wolfgang L. Gross, Jörg T. Epplen,