| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9262895 | Current Opinion in Immunology | 2005 | 7 Pages |
Abstract
Recent advances have shown the crucial role of histone-modifying enzymes in controlling gene activation and repression. This led to the 'histone code' hypothesis, which proposes that combinations of histone modifications work in concert to affect specific gene expression. Mounting evidence suggests that the class II transactivator modulates promoter accessibility by coordinating the recruitment of chromatin modifiers in a time-dependent fashion. MHC-II expression is exquisitely controlled by these highly specific, coordinated and dynamic interactions at the promoter.
Keywords
CDKp300/CBP associated factorRegulatory factor XRFXNF-YSRC-1CARM1Coactivator-associated arginine methyltransferase 1hMTPCAFMHC-IICREBTBPHDACCBPIFN-γCIITAMHC class IIinterferon-γNuclear factor YTAFHistone acetyltransferasehistone deacetylaseHistone MethyltransferaseCREB binding proteincAMP response element binding proteinTATA-binding proteinclass II transactivatorHATcyclin-dependent kinaseSteroid receptor coactivator 1
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Authors
Eleni Zika, Jenny P-Y Ting,