| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9267789 | Journal of Autoimmunity | 2005 | 6 Pages |
Abstract
Atorvastatin ameliorates EAM by inhibiting T cell responses and suppressing Th1-type and inflammatory cytokines production and this activity is independent of cholesterol reduction, whereas Th2-type cytokines production was promoted. Atorvastatin may have beneficial effects on myocarditis by modulating the Th1/Th2 balance. These results demonstrate an important role of Th1/Th2 polarization in the pathogenesis of EAM and suggest that HMG-CoA reductase blockade may be a promising new strategy for the treatment of organ specific autoimmune diseases.
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Authors
Liu Wei, Li Wei-Min, Gao Cheng, Sun Ning-Ling,