Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9267833 | Journal of Autoimmunity | 2005 | 8 Pages |
Abstract
The pSS sera resulted in significantly higher mean optical densities than those of the healthy controls (KRSE: 0.4149 vs 0.1494, p < 0.0001; GST-KRSE 0.4765 vs 0.1764, p < 0.0001). The immunological recognition with the recombinant fusion antigen was significantly better than that for the free peptide (p = 0.0068). The sensitivities of the assays were 77.5% (KRSE) and 97% (GST-KRSE). The results of the concentration-dependent inhibition assays by the two systems of peptide presentation indicated that the KRSE sequence is specific for pSS sera. This is the first demonstration of the antigenicity of a novel peptide fragment of the human m3AChR in pSS. The analysed peptide could be of diagnostic relevance.
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Authors
Ilona Marczinovits, László Kovács, Andrea György, Gábor K. Tóth, László Dorgai, János Molnár, Gyula Pokorny,