Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9270853 | Journal of Infection | 2005 | 13 Pages |
Abstract
Current evidence is largely restricted to the use of phage assays for the detection of rifampicin resistance in culture isolates. When used on culture isolates, these assays appear to have high sensitivity, but variable and slightly lower specificity. In contrast, evidence is lacking on the accuracy of these assays when they are directly applied to sputum specimens. If phage-based assays can be directly used on clinical specimens and if they are shown to have high accuracy, they have the potential to improve the diagnosis of MDR-TB. However, before phage assays can be successfully used in routine practice, several concerns have to be addressed, including unexplained false positives in some studies, potential for contamination and indeterminate results.
Keywords
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Authors
Madhukar Pai, Shriprakash Kalantri, Lisa Pascopella, Lee W. Riley, Arthur L. Reingold,