Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9271550 | Osteoarthritis and Cartilage | 2005 | 10 Pages |
Abstract
Transduction with SOX9 primed the passaged articular chondrocytes to regain a chondrocytic phenotype in pellet culture and to form a cartilaginous matrix, which was enhanced by growth factors. Following transduction, chondrocytes from OA joints showed a similar capacity for chondrogenic recovery as those from healthy joints, which suggested that OA does not permanently compromise the chondrocyte phenotype.
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Authors
Simon R. Ph.D., Ying Ph.D., Peraphan M.Sc., Lisa M. Tweats, Robert E. Ph.D., Timothy E. Ph.D.,