Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9271578 | Osteoarthritis and Cartilage | 2005 | 7 Pages |
Abstract
The uniformity of matrix volume per chondron throughout the adult human knee suggests that cell-scale biophysical and metabolic constraints may place limitations on cartilage thickness, mechanical properties, and remodelling mechanisms. Data may also aid the evaluation of cartilage tissue engineering treatments in a site-specific manner. Results indicate that joint locations which perform similar biomechanical functions have similar cell and matrix morphologies; findings may therefore also provide clues to understanding conditions under which focal lesions leading to osteoarthritis may occur.
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Authors
Thomas M. Ph.D., Ernst B. M.D., Hans-Jörg M.D.,