Article ID Journal Published Year Pages File Type
9271604 Osteoarthritis and Cartilage 2005 10 Pages PDF
Abstract
Chondrocyte CaR expression becomes up-regulated early in the course of spontaneous guinea pig knee OA. Chondrocyte CaR-mediated extracellular calcium-sensing promotes PTHrP expression, modulates the effects of PTHrP and IL-1, and promotes MMP-13 expression and TIMP-3 depletion. Our results implicate up-regulated extracellular calcium-sensing via the CaR as a novel mediator of OA progression.
Keywords
Related Topics
Health Sciences Medicine and Dentistry Immunology, Allergology and Rheumatology
Preview
Chondrocyte calcium-sensing receptor expression is up-regulated in early guinea pig knee osteoarthritis and modulates PTHrP, MMP-13, and TIMP-3 expression
Authors
, , , , , ,