Article ID Journal Published Year Pages File Type
9271607 Osteoarthritis and Cartilage 2005 13 Pages PDF
Abstract
We identified a cluster of genes as potential targets mediating the adverse effect of TGF-β such as fibrosis. Transcriptional regulation of ras GTPase and ubiquitin/proteasome pathways is likely to be a novel mechanism mediating the effect of TGF-β and its interaction with IL-1. These down-stream genes and pathways can be targets in future therapy.
Related Topics
Health Sciences Medicine and Dentistry Immunology, Allergology and Rheumatology
Authors
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