Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9271607 | Osteoarthritis and Cartilage | 2005 | 13 Pages |
Abstract
We identified a cluster of genes as potential targets mediating the adverse effect of TGF-β such as fibrosis. Transcriptional regulation of ras GTPase and ubiquitin/proteasome pathways is likely to be a novel mechanism mediating the effect of TGF-β and its interaction with IL-1. These down-stream genes and pathways can be targets in future therapy.
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Authors
N. Ph.D., K. M.D., P.M. Ph.D., H.M. Ph.D., E.L. B.Sc., K. M.D., W.B. Ph.D.,