Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9271862 | Osteoarthritis and Cartilage | 2005 | 10 Pages |
Abstract
Oestrogen depletion induced by OVX caused regional thinning of femoro-tibial cartilage, with biomechanical and histological changes suggestive of a disturbance in the content and/or structural organisation of the proteoglycan and collagen macromolecular assembly. The observed up-regulation of cartilage iNOS suggests a possible mechanism for these matrix changes.
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Authors
M.A. Ph.D., R.C. Ph.D., R.A. Ph.D., M.M. Ph.D., G.A.C. M.D., Ph.D., P. Ph.D.,