Vulnerability to ROS-induced cell death in ageing articular cartilage: The role of antioxidant enzyme activity

Article ID	Journal	Published Year	Pages	File Type
9271931	Osteoarthritis and Cartilage	2005	9 Pages	PDF

Abstract

Substantial loss of chondrocytes occurs in rat articular cartilage which may result from increased vulnerability to elevated intracellular ROS levels, consequent upon a decline in antioxidant defence.

Keywords

Stereology dihydrorhodamine 123 Ageing Superoxide dismutase Cell death Rat Catalase Chondrocytes glutathione peroxidase Reactive oxygen species

Related Topics

Health Sciences Medicine and Dentistry Immunology, Allergology and Rheumatology

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Vulnerability to ROS-induced cell death in ageing articular cartilage: The role of antioxidant enzyme activity

Authors

N. B.Sc., M.B., Ch.B. (Hons.), M.R.C.S., H. B.Sc., M.B., B.S., C. Ph.D., C. H.N.D., P.E.M. F.R.C.S(I)., F.R.C.S. (Plast), T. B.Sc., Ph.D.,