Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9271974 | Osteoarthritis and Cartilage | 2005 | 8 Pages |
Abstract
The results of this study indicate that, following single impact load, CPC can be stimulated in mature articular cartilage in vitro. These CPC and the cells arising from them appear to represent the cartilage's response to damage. The timing of the appearance of CPC and their overall numbers can be significantly increased by FGF-2, providing further evidence for an important role for FGF-2 in modulating cartilage repair. These results indicate that further study into the mechanisms of repair in mature cartilage using this in vitro model are vital in understanding the repair capacity of mature cartilage.
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Authors
F.M.D. Ph.D., E.A. Ph.D., M.E. Ph.D.,