Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9273518 | Seminars in Immunology | 2005 | 10 Pages |
Abstract
Thymic involution is the hallmark of hematopoietic aging. Because T cell differentiation is a multistep process that occurs non-cell autonomously, aging defects can occur at multiple points along the developmental pathway, both in the T progenitors themselves and in the thymic stromal cells that support their development. Here we review the evidence for age-related thymopoiesis defects at key steps in the production of naïve mature T cells, highlighting the importance of the interaction between stromal aging and progenitor aging.
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Authors
Valerie P. Zediak, Avinash Bhandoola,