Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9273520 | Seminars in Immunology | 2005 | 6 Pages |
Abstract
It is generally accepted that thymic involution commences, or at least accelerates, at puberty due to increases in sex steroid and declines in growth hormone production. As a result of these hormonal changes, the development of the most immature intrathymic progenitors is blocked. However, aspects of this model are now being questioned. The present chapter re-evaluates a number of findings on which traditional models of thymic involution are based and reviews new data that, taken together, indicate a need to revise current views of thymic involution.
Keywords
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Authors
Encarnacion Montecino-Rodriquez, Hyeyoung Min, Kenneth Dorshkind,