Article ID Journal Published Year Pages File Type
9273522 Seminars in Immunology 2005 8 Pages PDF
Abstract
Survival and homeostatic division of naive CD4 T cells is regulated by the cellular and non-cellular milieu and together these processes ensure that a population of naive CD4 T cells persists into old age. However, the naive CD4 T cells from aged animals show reduced IL-2 production, proliferation, helper function and effector generation and memory function. We explore here whether the age-related defects in naive CD4 T cells are due to the aged environment from which they come or to intrinsic defects that are caused by homeostasis and their long lifespan.
Related Topics
Life Sciences Immunology and Microbiology Immunology
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