Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9273522 | Seminars in Immunology | 2005 | 8 Pages |
Abstract
Survival and homeostatic division of naive CD4 T cells is regulated by the cellular and non-cellular milieu and together these processes ensure that a population of naive CD4 T cells persists into old age. However, the naive CD4 T cells from aged animals show reduced IL-2 production, proliferation, helper function and effector generation and memory function. We explore here whether the age-related defects in naive CD4 T cells are due to the aged environment from which they come or to intrinsic defects that are caused by homeostasis and their long lifespan.
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Authors
Susan Swain, Karen Clise-Dwyer, Laura Haynes,