Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9273572 | Seminars in Immunology | 2005 | 7 Pages |
Abstract
The λ5 and VpreB genes encode the components of the surrogate light-chain, which forms part of the pre-B cell receptor. In mouse, the λ5 and VpreB1 genes of mouse are closely linked and coordinately regulated by a locus control region (LCR). Activation of the genes in pro-B cells depends on the combined effects of early B cell factor (EBF) and the E2A factors E12 and E47. Silencing of λ5 expression in mature B cells occurs through the action of Ikaros on the gene promoter where it may compete for binding of EBF and initiate the formation of a silent chromatin structure.
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Authors
Pierangela Sabbattini, Niall Dillon,