Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9273928 | Transplant Immunology | 2005 | 7 Pages |
Abstract
In this retrospective study, we analyzed the effect of the presence of anti-donor preformed alloantibodies in 268 liver allograft transplants. Crossmatches were performed by complement-dependent cytotoxicity (CDC) assay and HLA antibody screening by flow cytometry (FlowPRAâ¢). Positive anti-donor crossmatch was detected in 5.2% of transplants. Acute rejection frequency in +CDC crossmatch patients was not different from that observed in âCDC crossmatch patients. None of the patients transplanted with +CDC crossmatch developed chronic rejection, but they showed a significantly lower allograft survival rate, and the majority of them had allograft failures before the end of the first post-transplant year, mainly within the 3 first months. Indeed, positive FlowPRA determination was concordant with data from the CDC assay. In conclusion, these findings show a direct correlation between the presence of anti-donor preformed antibodies and a poor allograft survival in liver transplant.
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Authors
Manuel Muro, Luis Marin, Manuel Miras, Rosa Moya-Quiles, Alfredo Minguela, Francisco Sánchez-Bueno, Juan Bermejo, Ricardo Robles, Pablo RamÃrez, Ana GarcÃa-Alonso, Pascual Parrilla, MarÃa R. Álvarez-López,